Careers

Reporting to: Director, ASO Design and Discovery
Hours: Full-Time
Location: On-site in 9410 Carroll Park Dr, San Diego, CA 92121
Compensation: $130K-$160K / annual + benefits

n-Lorem Foundation
Though n-Lorem is pioneering a novel non-profit model, to provide personalized experimental ASO treatments for free, for life to patients with the rarest of mutations (nano-rare), we are functionally a biotechnology company. We have a large and growing portfolio of ASO medicine discovery programs, more than 35 ASO medicines in development and multiple clinical programs.

If you are a scientist with biotechnology experience and would like to join a cohesive, experience team committed to the belief that we can change the world one patient, one family at a time, we may have a position for you.

n-Lorem founder, chairman and CEO, Stanley T. Crooke, M.D., Ph.D., was presented with the 2022 Roy Vagelos Pro Bono Humanum Award for Global Health Equity of the Prix Galien. https://youtu.be/N7UwdQUZFmY

Job Overview
n-Lorem is seeking a passionate, organized, detail- and action-oriented individual to join our team as a Senior Bioinformatics Scientist. In this role, you will be instrumental in advancing our ASO design software by making original contributions and integrating experimental findings from basic antisense research projects and publicly available datasets. You will design, process, analyze, and interpret RNA genomics experiments and datasets as well as maintain moderately complex data processing pipelines. In addition, you will integrate internal or publicly available datasets into analysis pipelines or tools, and you will interpret and present computational results for biological significance and therapeutic relevance.

You will work across many functional teams which will require clear and timely communication, and the ability to quickly adjust to changing priorities. No two days will be the same and flexibility will be key as an important member of our fast-paced growing team

Key Responsibilities:

• Design, process, analyze, and interpret RNA genomics experiments and datasets.
• Make significant contributions and advance ASO Design software and algorithms by integrating n-Lorem’s core research findings and available, published datasets.
• Integrate internal or publicly available datasets into analysis pipelines or tools.
• Apply complex bio-informatic concepts to design, develop, modify and evaluate software programs and lab tools.
• Provide computational support to pre-clinical drug discovery and screening laboratory.
• Interpret and present computational results for biological significance and therapeutic relevance.
• Prioritize work in a fast-paced environment with evolving project priorities.
• Demonstrate ability to meet deadlines with changing priorities and manage multiple projects with different team members.
• Ability to communicate technical information in a clear and concise manner.
• Extend or create bio-informatic tools for the purpose of data analysis, machine learning and software optimization.
• Update and validate genome databases used in the lab.

Requirements

•  US work authorization
• Must have PhD or MS with experience in computational biology, statistical genetics, bioinformatics, biomedical engineering, statistics, computer science, machine learning or a related field.
• Must have advanced theoretical knowledge and conceptual experience to apply bioinformatics in a RNA research laboratory and analyze RNA related data.
• Must have proven ability to troubleshoot and problem solve computational work.
• Must have a proven track record in the analysis, visualization, and interpretation of diverse. genomic data types including next-generation sequencing (NGS) data.
• Must have proficiency in Python, Java, C and/or R and relevant data science packages.
• Must have basic knowledge of RNA Biology.
• Ability to work in laboratory for which BSL-2 training is required.
• Must be able to demonstrate ability to work closely with wet lab members and experimental collaborators to design studies and develop analyses to answer scientific questions.
• Must be detail-oriented and self-motivated approach to problem solving with excellent analytical rigor.
• Must be able to work with a team-oriented growth mindset that welcomes feedback from others and supports other team members; strong collaboration skills to work across teams and functions.
• Must have excellent presentation and communication skills, including the ability to tailor scientific content to audiences with different backgrounds.
• Proficiency with MS Office including Word, Excel, and PowerPoint, Teams, and SharePoint.
• Must have the ability to sitting, standing, stepping up, standing on a step stool periodically and bending for long periods of time.

Qualifications

• Experience writing and maintaining Nextflow DSL2 data processing pipelines.
• Proven ability to develop tools, scripts and perform bio-informatic analysis of RNA related data used in biomedical studies.
• Thorough knowledge of bioinformatics methods, programming design, and data structures.
• Demonstrated conceptual and theoretical experience in bioinformatic analysis of RNA related and oligo related data.
• Knowledge of best-practice pipelines in RNA genomics, including but not limited to variant-calling, high-throughput protein: RNA interaction studies, and RNA structure analysis.
• Experience in applying computational methods and bioinformatics tools to large- scale data including proficiency with Linux/Unix systems and high performance computing, preferably in the Microsoft Azure environment.
• Familiarity with application of statistical modeling and machine learning to biological problems and datasets.
• Firm understanding of basics in RNA molecular biology and biological systems.
• Previous work with oligonucleotide therapeutics is a strong plus.

n-Lorem offers a competitive benefits package including medical, dental, vision, 403(b) and 4 weeks paid vacation. n-Lorem is a small foundation with an extraordinary mission, to provide hope and potentially help to nano-rare patients today. Every employee in our organization is a significant contributor to this mission. We know that our work could have a profound impact on the life of a patient today.

To apply for this position please click the link below.

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